Characterization of the tumor microenvironment through immunoprofiling has become an
essential resource for the understanding of the complex immune cell interactions and the …

The brain is one of the most complex living tissue types and is composed of an exceptional
diversity of cell types displaying unique functional connectivity. Single-cell RNA sequencing …

Transferring annotations of single-cell-, spatial-and multi-omics data is often challenging
owing both to technical limitations, such as low spatial resolution or high dropout fraction …

Spatial transcriptomics technologies with high resolution often lack high sensitivity in mRNA
detection. Here we report a dendrimeric DNA coordinate barcoding design for spatial RNA …

Spatially resolved transcriptomics involves a set of emerging technologies that enable the
transcriptomic profiling of tissues with the physical location of expressions. Although a …

Olfactory sensory neurons (OSNs) convert the stochastic choice of one of> 1,000 olfactory
receptor (OR) genes into precise and stereotyped axon targeting of OR-specific glomeruli in …

In olfactory systems, convergence of sensory neurons onto glomeruli generates a map of
odorant receptor identity. How glomerular maps relate to sensory space remains unclear …

Background Olfactory dysfunction is highly associated with chronic rhinosinusitis with nasal
polyps (CRSwNP), and the severity of loss has been linked with biomarkers of type 2 …

Olfaction depends on lifelong production of sensory neurons from CXCR4 expressing
neurogenic stem cells. Signaling by CXCR4 depends on the concentration of CXCL12 …

Background: Loss of smell is a part of the diagnostic criteria for CRSwNP. Although the
mechanistic understanding is poor, inhibition of IL-4Rα and IL-4/IL-13 signaling improves …