Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of COVID-19, is
reported to increase the rate of mortality worldwide. COVID-19 is associated with acute …

The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological
roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are …

The normal brain development and function are delicately driven by an ever-changing
milieu of steroid hormones arising from fetal, placental, and maternal origins. This reliance …

Heart failure (HF) is a growing epidemic with high morbidity and mortality at an international
scale. The apelin–APJ receptor pathway has been implicated in HF, making it a promising …

Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its
receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has …

Apelin is an endogenous ligand of G protein-coupled receptor APJ. In recent years, many
studies have shown that the apelin/APJ system has neuroprotective properties, such as anti …

ABSTRACT Elabela (ELA), Apela or Toddler peptide is a hormone peptide belonging to the
adipokine group and a component of apelinergic system, discovered in 2013-2014. Given its …

Introduction: Apelin, a bioactive peptide, is the endogenous ligand of APJ, a G protein-
coupled receptor which is widely expressed in peripheral tissues and in the central nervous …

This study was aimed at investigating whether Elabela (ELA) gene therapy can promote
angiogenesis in the treatment of myocardial infarction (MI). The fusion expression plasmid …

Diabetic cardiomyopathy—pathophysiological heart remodelling and dysfunction that occurs
in absence of coronary artery disease, hypertension and/or valvular heart disease—is a …