With an increase in life expectancy and the popularity of high-intensity exercise, the
frequency of tendon and ligament injuries has also increased. Owing to the specificity of its …

The extracellular microenvironment regulates many of the mechanical and biochemical cues
that direct musculoskeletal development and are involved in musculoskeletal disease. The …

Skeletal shape depends on the transmission of contractile muscle forces from tendon to
bone across the enthesis. Loss of muscle loading impairs enthesis development, yet little is …

Actin is a central mediator between mechanical force and cellular phenotype. In tendons, it
is speculated that mechanical stress deprivation regulates gene expression by reducing …

Tendinopathy is a debilitating condition marked by degenerative changes in the tendons. Its
complex pathophysiology involves intrinsic, extrinsic, and physiological factors. While its …

Degenerative tendinopathy results from the accumulation of minor injuries following
unsuccessful tendon repair during acute tendon injuries. The process of tendon repair is …

Mechanobiology is a rapidly advancing field, with growing evidence that mechanical
signaling plays key roles in health and disease. To accelerate mechanobiology-based drug …

A major risk factor for tendinopathy is tendon overuse (ie, fatigue loading). Fatigue loading of
tendon damages the extracellular matrix and induces tissue degeneration. However, the …

Tendon injury is one of the most common disorders of the musculoskeletal system, with a
higher likelihood of occurrence in elderly individuals and athletes. In posthealing tendons …

Tendon afflictions constitute a significant share of musculoskeletal diseases and represent a
primary cause of incapacity worldwide. Unresolved/chronic inflammatory states have been …