The emerging role of extracellular vesicles in fungi: A double-edged sword

Y Lai, B Jiang, F Hou, X Huang, B Ling, H Lu… - Frontiers in …, 2023 - frontiersin.org
Fungi are eukaryotic microorganisms found in nature, which can invade the human body
and cause tissue damage, inflammatory reactions, organ dysfunctions, and diseases. These …

Harnessing the immune response to fungal pathogens for vaccine development

A Rivera, J Lodge, C Xue - Annual review of microbiology, 2022 - annualreviews.org
Invasive fungal infections are emerging diseases that kill over 1.5 million people per year
worldwide. With the increase of immunocompromised populations, the incidence of invasive …

The development of extracellular vesicle markers for the fungal phytopathogen Colletotrichum higginsianum

BD Rutter, TTH Chu, JF Dallery, KK Zajt… - Journal of …, 2022 - Wiley Online Library
Fungal phytopathogens secrete extracellular vesicles (EVs) associated with enzymes and
phytotoxic metabolites. While these vesicles are thought to promote infection, defining the …

Immunomodulatory potential of fungal extracellular vesicles: Insights for therapeutic applications

S Nenciarini, D Cavalieri - Biomolecules, 2023 - mdpi.com
Extracellular vesicles (EVs) are membranous vesicular organelles that perform a variety of
biological functions including cell communication across different biological kingdoms. EVs …

The paradoxical and still obscure properties of fungal extracellular vesicles

AC Piffer, D Kuczera, ML Rodrigues, L Nimrichter - Molecular Immunology, 2021 - Elsevier
Early compositional studies of fungal EVs revealed a complex combination of biomolecules,
including proteins, lipids, glycans, polysaccharides, nucleic acid and pigments, indicating …

Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis

RJA de Castro, CL Marina, A Sturny-Leclère… - PLoS …, 2023 - journals.plos.org
Macrophages play a key role in disseminated cryptococcosis, a deadly fungal disease
caused by Cryptococcus neoformans. This opportunistic infection can arise following the …

Characteristics and potential clinical applications of the extracellular vesicles of human pathogenic Fungi

A Ullah, Y Huang, K Zhao, Y Hua, S Ullah, M Rahman… - BMC microbiology, 2023 - Springer
Extracellular vesicles (EVs) are a heterogeneous group of lipid membrane-enclosed
compartments that contain different biomolecules and are released by almost all living cells …

Structure, composition and biological properties of fungal extracellular vesicles

J Rizzo, A Taheraly, G Janbon - MicroLife, 2021 - academic.oup.com
Extracellular vesicles (EVs) are lipidic nanosized particles that deliver a highly complex
molecular cargo between cells and organisms and may serve numerous functions in …

[HTML][HTML] Pathogenicity and Growth Conditions Modulate Fonsecaea Extracellular Vesicles' Ability to Interact With Macrophages

LO Las-Casas, CLF Marina, RJA de Castro… - Frontiers in Cellular …, 2022 - frontiersin.org
Chromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous mycosis caused by
black, dimorphic, and filamentous fungi of the Dematiaceae family, such as species of the …

Extracellular Vesicle Formation in Cryptococcus deuterogattii Impacts Fungal Virulence and Requires the NOP16 Gene

RF Castelli, A Pereira, L Honorato, A Valdez… - Infection and …, 2022 - Am Soc Microbiol
Small molecules are components of fungal extracellular vesicles (EVs), but their biological
roles are only superficially known. NOP16 is a eukaryotic gene that is required for the activity …