[HTML][HTML] Abnormal calcium handling in Duchenne muscular dystrophy: mechanisms and potential therapies

S Mareedu, ED Million, D Duan, GJ Babu - Frontiers in physiology, 2021 - frontiersin.org
Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by the
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …

[HTML][HTML] Targeting Nrf2 for the treatment of Duchenne muscular dystrophy

S Kourakis, CA Timpani, JB de Haan, N Gueven… - Redox biology, 2021 - Elsevier
Imbalances in redox homeostasis can result in oxidative stress, which is implicated in
various pathological conditions including the fatal neuromuscular disease Duchenne …

[HTML][HTML] “The Social Network” and muscular dystrophies: the lesson learnt about the niche environment as a target for therapeutic strategies

O Cappellari, P Mantuano, A De Luca - Cells, 2020 - mdpi.com
The muscle stem cells niche is essential in neuromuscular disorders. Muscle injury and
myofiber death are the main triggers of muscle regeneration via satellite cell activation …

[HTML][HTML] Arachidonic acid metabolism as a therapeutic target in AKI-to-CKD transition

XJ Li, P Suo, YN Wang, L Zou, XL Nie… - Frontiers in …, 2024 - frontiersin.org
Arachidonic acid (AA) is a main component of cell membrane lipids. AA is mainly
metabolized by three enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and …

[HTML][HTML] Muscle metabolic remodelling patterns in Duchenne muscular dystrophy revealed by ultra-high-resolution mass spectrometry imaging

I Dabaj, J Ferey, F Marguet, V Gilard, C Basset… - Scientific Reports, 2021 - nature.com
Duchenne muscular dystrophy (DMD) is a common and severe X-linked myopathy,
characterized by muscle degeneration due to altered or absent dystrophin. DMD has no …

Prostaglandin D2 signaling and cardiovascular homeostasis

D Kong, Y Yu - Journal of Molecular and Cellular Cardiology, 2022 - Elsevier
Cardiovascular diseases are the leading cause of death worldwide. A chronic inflammatory
response is a common pathological alteration in diverse cardiovascular diseases …

Targeting the DP2 receptor alleviates muscle atrophy and diet‐induced obesity in mice through oxidative myofiber transition

H Ning, H Ren, Y Zhao, HF Yin, Z Gan… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Mammalian skeletal muscles consist of two main fibre types: slow‐twitch (type I,
oxidative) and fast‐twitch (type IIa, fast oxidative; type IIb/IIx, fast glycolytic). Muscle fibre …

Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia

K Sataranatarajan, G Pharaoh, JL Brown, R Ranjit… - Geroscience, 2020 - Springer
Mice lacking the superoxide anion scavenger CuZn superoxide dismutase (Sod1−/− mice)
develop a number of age-related phenotypes, including an early progression of muscle …

[HTML][HTML] Prenatal diagnosis of Duchenne muscular dystrophy revealed a novel mosaic mutation in Dystrophin gene: a case report

Y Wang, Y Chen, SM Wang, X Liu, YN Gu… - BMC Medical Genetics, 2020 - Springer
Abstracts Background Duchenne muscular dystrophies (DMDs) are X-linked recessive
neuromuscular disorders with malfunction or absence of the Dystrophin protein. Precise …

[HTML][HTML] Vascular therapy for Duchenne muscular dystrophy (DMD)

S Thapa, S Elhadidy, A Asakura - Faculty Reviews, 2023 - ncbi.nlm.nih.gov
Duchenne muscular dystrophy (DMD) is a progressive disease characterized by the wasting
of the muscles that eventually lead to difficulty moving and, ultimately, premature death from …