[HTML][HTML] Abnormal calcium handling in Duchenne muscular dystrophy: mechanisms and potential therapies
Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by the
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …
[HTML][HTML] Targeting Nrf2 for the treatment of Duchenne muscular dystrophy
Imbalances in redox homeostasis can result in oxidative stress, which is implicated in
various pathological conditions including the fatal neuromuscular disease Duchenne …
various pathological conditions including the fatal neuromuscular disease Duchenne …
[HTML][HTML] “The Social Network” and muscular dystrophies: the lesson learnt about the niche environment as a target for therapeutic strategies
O Cappellari, P Mantuano, A De Luca - Cells, 2020 - mdpi.com
The muscle stem cells niche is essential in neuromuscular disorders. Muscle injury and
myofiber death are the main triggers of muscle regeneration via satellite cell activation …
myofiber death are the main triggers of muscle regeneration via satellite cell activation …
[HTML][HTML] Arachidonic acid metabolism as a therapeutic target in AKI-to-CKD transition
XJ Li, P Suo, YN Wang, L Zou, XL Nie… - Frontiers in …, 2024 - frontiersin.org
Arachidonic acid (AA) is a main component of cell membrane lipids. AA is mainly
metabolized by three enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and …
metabolized by three enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and …
[HTML][HTML] Muscle metabolic remodelling patterns in Duchenne muscular dystrophy revealed by ultra-high-resolution mass spectrometry imaging
I Dabaj, J Ferey, F Marguet, V Gilard, C Basset… - Scientific Reports, 2021 - nature.com
Duchenne muscular dystrophy (DMD) is a common and severe X-linked myopathy,
characterized by muscle degeneration due to altered or absent dystrophin. DMD has no …
characterized by muscle degeneration due to altered or absent dystrophin. DMD has no …
Prostaglandin D2 signaling and cardiovascular homeostasis
D Kong, Y Yu - Journal of Molecular and Cellular Cardiology, 2022 - Elsevier
Cardiovascular diseases are the leading cause of death worldwide. A chronic inflammatory
response is a common pathological alteration in diverse cardiovascular diseases …
response is a common pathological alteration in diverse cardiovascular diseases …
Targeting the DP2 receptor alleviates muscle atrophy and diet‐induced obesity in mice through oxidative myofiber transition
H Ning, H Ren, Y Zhao, HF Yin, Z Gan… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Mammalian skeletal muscles consist of two main fibre types: slow‐twitch (type I,
oxidative) and fast‐twitch (type IIa, fast oxidative; type IIb/IIx, fast glycolytic). Muscle fibre …
oxidative) and fast‐twitch (type IIa, fast oxidative; type IIb/IIx, fast glycolytic). Muscle fibre …
Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia
Mice lacking the superoxide anion scavenger CuZn superoxide dismutase (Sod1−/− mice)
develop a number of age-related phenotypes, including an early progression of muscle …
develop a number of age-related phenotypes, including an early progression of muscle …
[HTML][HTML] Prenatal diagnosis of Duchenne muscular dystrophy revealed a novel mosaic mutation in Dystrophin gene: a case report
Y Wang, Y Chen, SM Wang, X Liu, YN Gu… - BMC Medical Genetics, 2020 - Springer
Abstracts Background Duchenne muscular dystrophies (DMDs) are X-linked recessive
neuromuscular disorders with malfunction or absence of the Dystrophin protein. Precise …
neuromuscular disorders with malfunction or absence of the Dystrophin protein. Precise …
[HTML][HTML] Vascular therapy for Duchenne muscular dystrophy (DMD)
Duchenne muscular dystrophy (DMD) is a progressive disease characterized by the wasting
of the muscles that eventually lead to difficulty moving and, ultimately, premature death from …
of the muscles that eventually lead to difficulty moving and, ultimately, premature death from …