Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for
adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Roxadustat is a recently approved hypoxia-inducible factor prolyl hydroxylase inhibitor that
has demonstrated favorable safety and efficacy in the treatment of renal anemia. Recent …

Prolyl hydroxylase domain enzyme inhibitors (PHDIs) stabilize hypoxia-inducible factors
(HIFs), and are protective in models of acute ischemic and inflammatory kidney disease …

Alterations in mitochondrial metabolism influence cell differentiation and growth. This
process is regulated by the activity of 2-oxoglutarate (2OG)-dependent dioxygenases …

Anemia is a hallmark of chronic kidney disease (CKD), worsens with disease progression,
and profoundly affects a patient's well-being. Major pathogenic factors are inadequate …

Introduction: Hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) enzymes are
major therapeutic targets of anemia and ischemic/hypoxia diseases. To overcome safety …

Collagen biosynthesis requires several co-and post-translational modifications of lysine and
proline residues to form structurally and functionally competent collagen molecules …

Complement cascade is a defence mechanism useful for eliminating pathogenic
microorganisms and damaged cells. However, activation of alternative complement system …

Hypoxia-inducible factors (HIFs) are transcription factors that regulate erythropoietin (EPO)
synthesis and red blood cell (RBC) production. Prolyl-4-hydroxylase domain (PHD) …

Proper deposition of the extracellular matrix and its major components, the collagens, is
essential for endochondral ossification and bone mass accrual. Collagen prolyl 4 …