abstract Bronchial asthma is characterized by chronic airway inflammation, which manifests
clinically as variable airway narrowing (wheezes and dyspnea) and cough. Long-standing …

This review covers basic aspects of histone modification and the role of posttranslational
histone modifications in the development of allergic diseases, including the immune …

Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) characterized by a type 2
immune signature often have severe and recurrent disease. Lower airway conditions such …

Background Aspirin-exacerbated respiratory disease (AERD) comprises the triad of chronic
rhinosinusitis with nasal polyps (CRSwNP), asthma, and intolerance to inhibitors of the …

Background Group 2 innate lymphoid cells (ILC2s) are involved in the initial phase of type 2
inflammation and can amplify allergic immune responses by orchestrating other type 2 …

Aspirin-Exacerbated Respiratory Disease About 7% of patients with asthma have mucosal
swelling, nasal polyps, and worsening of asthma in response to aspirin and other COX-1 …

Prostaglandins are synthesized through the metabolism of arachidonic acid via the
cyclooxygenase pathway. There are five primary prostaglandins, PGD 2, PGE 2, PGF 2, PGI …

Summary Cyclooxygenase 2 (COX‐2: official gene symbol–PTGS2) has long been regarded
as playing a pivotal role in the pathogenesis of airway inflammation in respiratory diseases …

Background Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma,
chronic rhinosinusitis with nasal polyps (CRSwNP), and an intolerance of medications that …

In a process known as overt degranulation, mast cells can release all at once a diverse array
of products that are preformed and present within cytoplasmic granules. This occurs typically …