Promoting bone regeneration and repairing defects are urgent and critical challenges in
orthopedic clinical practice. Research on bone substitute biomaterials is essential for …

Simple Summary For the research and development of drug discovery, it is of prime
importance to construct the three-dimensional (3D) tissue models in vitro. To this end, the …

Successful launch of a commercial drug requires significant investment of time and financial
resources wherein late-stage failures become a reason for catastrophic failures in drug …

Cardiac cell therapy holds a real promise for improving heart function and especially of the
chronically failing myocardium. Embedding cells into 3D biodegradable scaffolds may better …

Chitosan is produced by deacetylating the abundant natural chitin polymer. It has been
employed in a variety of applications due to its unique solubility as well as its chemical and …

The crosstalk between endothelial cells and cardiomyocytes has emerged as a requisite for
normal cardiac development, but also a key pathogenic player during the onset and …

The introduction of more relevant cell models in early preclinical drug discovery, combined
with high-content imaging and automated analysis, is expected to increase the quality of …

Cardiovascular diseases remain the leading cause of human mortality worldwide. Some
severe symptoms, including myocardial infarction and heart failure, are difficult to heal …

Abstract Development of cardiac fibrosis and arrhythmias is controlled by the activity of and
communication between cardiomyocytes and fibroblasts in the heart. Myocyte-fibroblast …

Functionalized chitosan nanocomposites have been studied for wound dressing
applications due to their excellent antibacterial and anti-fungal properties. Polysaccharides …