The nonstructural proteins directing coronavirus RNA synthesis and processing
Coronaviruses are animal and human pathogens that can cause lethal zoonotic infections
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …
[HTML][HTML] RNA dependent RNA polymerases: insights from structure, function and evolution
RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA
viruses that is indispensable for replicating the genome as well as for carrying out …
viruses that is indispensable for replicating the genome as well as for carrying out …
Origins and evolution of the global RNA virome
Viruses with RNA genomes dominate the eukaryotic virome, reaching enormous diversity in
animals and plants. The recent advances of metaviromics prompted us to perform a detailed …
animals and plants. The recent advances of metaviromics prompted us to perform a detailed …
RNA‐dependent RNA polymerase of SARS‐CoV‐2 as a therapeutic target
Y Wang, V Anirudhan, R Du, Q Cui… - Journal of medical …, 2021 - Wiley Online Library
The global pandemic caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐
CoV‐2), named coronavirus disease 2019, has infected more than 8.9 million people …
CoV‐2), named coronavirus disease 2019, has infected more than 8.9 million people …
Homology-based identification of a mutation in the coronavirus RNA-dependent RNA polymerase that confers resistance to multiple mutagens
Positive-sense RNA viruses encode RNA-dependent RNA polymerases (RdRps) essential
for genomic replication. With the exception of the large nidoviruses, such as coronaviruses …
for genomic replication. With the exception of the large nidoviruses, such as coronaviruses …
Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses
KC Lehmann, A Gulyaeva… - Nucleic acids …, 2015 - academic.oup.com
RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that catalyzes the
synthesis of their RNA (s). In the case of positive-stranded RNA viruses belonging to the …
synthesis of their RNA (s). In the case of positive-stranded RNA viruses belonging to the …
[HTML][HTML] Structure and function of the Zika virus full-length NS5 protein
The recent outbreak of Zika virus (ZIKV) has infected over 1 million people in over 30
countries. ZIKV replicates its RNA genome using virally encoded replication proteins …
countries. ZIKV replicates its RNA genome using virally encoded replication proteins …
Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase
P Gong, OB Peersen - … of the National Academy of Sciences, 2010 - National Acad Sciences
Positive-strand RNA viruses include a large number of human and animal pathogens whose
essential RNA-dependent RNA polymerases (RdRPs) share a structurally homologous core …
essential RNA-dependent RNA polymerases (RdRPs) share a structurally homologous core …
[HTML][HTML] The Big Bang of picorna-like virus evolution antedates the radiation of eukaryotic supergroups
The recent discovery of RNA viruses in diverse unicellular eukaryotes and developments in
evolutionary genomics have provided the means for addressing the origin of eukaryotic RNA …
evolutionary genomics have provided the means for addressing the origin of eukaryotic RNA …
[HTML][HTML] Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors
S Gao, T Huang, L Song, S Xu, Y Cheng… - … Pharmaceutica Sinica B, 2022 - Elsevier
Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.
Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the …
Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the …