Personalised and targeted interventions have revolutionised cancer treatment and
dramatically improved survival rates in recent decades. Nonetheless, effective pain …

Bone cancer pain (BCP) is a common pathologic pain associated with destruction of bone
and pathological reconstruction of nervous system. Current treatment strategies in clinical is …

Bone cancer pain is a common symptom in cancer patients with bone metastases and its
underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates …

Simple Summary The mechanisms that underlie pain resulting from metastatic bone disease
remain elusive. This translates to a clinical and socioeconomic burden—targeted therapy is …

Nerve terminals within the tumor microenvironment as potential pain-mitigating targets for
local infiltration analgesia is relatively less explored. In this study, we examine the role of key …

Cancer pain is a growing problem, especially with the substantial increase in cancer
survival. Reports indicate that bone metastasis, whose primary symptom is bone pain …

Pain is an uncomfortable condition that is clinically associated with many diseases such as
cancer/tumor, metabolic disorders such as diabetes, neurological diseases such as epilepsy …

目的探讨复方守宫散(Compound Shougong powder, CSP) 通过肿瘤坏死因子α (TNF-α)
信号通路对骨癌痛大鼠痛觉敏化机制的影响. 方法通过注射Lewis 肺癌细胞建立肺癌骨癌痛大鼠 …

Objective: The purpose of this study was to evaluate the use of in vivo calcium imaging to
monitor activity in joint afferents and group-housed home cage monitoring for the …