Osteoporosis is characterized by a decline in bone mineral density (BMD) and increased
fracture risk. Free radicals and antioxidant systems play a central role in bone remodeling …

Osteoporosis, a disorder of skeletal fragility, is common in the elderly, and its prevalence is
increasing as more individuals with low bone mineral density (BMD), the strongest predictor …

A key assumption in studying mRNA expression is that it is informative in the prediction of
protein expression. However, only limited studies have explored the mRNA‐protein …

Osteoporotic fractures are a major cause of morbidity and mortality in ageing populations.
Osteoporosis, defined as low bone mineral density (BMD) and associated fractures, have …

Osteoporosis, a highly heritable disease, is characterized mainly by low bone-mineral
density (BMD), poor bone geometry, and/or osteoporotic fractures (OF). Copy-number …

Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease
caused by mutations in sarcomeric genes. However, extensive genetic screening failed to …

Three of 20 patients with juvenile osteoporosis were found to have a heterozygous mutation
in the LRP5 gene. No mutations were found in the type I collagen genes. Mutations in the …

Abstract Introduction: Insulin‐like factor 3 (INSL3) is produced primarily by testicular Leydig
cells. It acts by binding to its specific G protein–coupled receptor RXFP2 (relaxin family …

The insulin-like growth factor (IGF) regulatory system is critical for skeletal growth and
maintenance. Initially there was great hope that the recombinant IGFs might be used …

Osteoporosis is characterized by low bone mineral density and structural deterioration of
bone tissue, leading to an increased risk of fractures. It is the most common metabolic bone …