HIV-associated dementia (HAD) is an important complication of the central nervous system
in patients who are infected with HIV-1. Although the incidence of HAD has markedly …

HIV-1 replication in the central nervous system (CNS) is typically limited by the availability of
target cells. HIV-1 variants that are transmitted and dominate the early stages of infection …

Summary The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus
worldwide, reaching near fixation in a matter of months. Here we show that D614G was …

Objective. We report data on 11 patients with neurological symptoms and human
immunodeficiency virus (HIV) cerebrospinal fluid (CSF) viremia contrasting with suppressed …

Genome sequences of transmitted/founder (T/F) HIV-1 have been inferred by analyzing
single genome amplicons of acute infection plasma viral RNA in the context of a …

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS)
can lead to the development of HIV-1-associated dementia (HAD). We examined the …

HIV-associated central nervous system (CNS) injury continues to be clinically significant in
the modern era of HIV infection and therapy. A substantial proportion of patients with …

Monocytes and macrophages play critical roles in HIV transmission, viral spread early in
infection, and as a reservoir of virus throughout infection. There has been a recent …

The third variable region, V3, of the gp120 surface envelope glycoprotein is an
approximately 35-residue-long, frequently glycosylated, highly variable, disulfide-bonded …

Primary human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimers
[(gp120/gp41) 3] typically exist in a metastable closed conformation (state 1). Binding the …