In late 1993 and early 1994, two distinct lines of research converged on a new tumor
suppressor gene located on human chromosome 9p21. The órst report was of the existence …

CDKN2A, the gene encoding the cell-cycle inhibitor p16 CDKN2A, was first identified in
1994. Since then, somatic mutations have been observed in many cancers and germline …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

A. Single-transmembrane segment receptors B. Seven-transmembrane receptors C. Steroid
hormones D. Intracellular second messengers IV. Cyclins and CKIs in Endocrine Tumors A …

Human germ cell tumours comprise a heterogeneous group of neoplasms. In the testis,
three entities are distinguished, the teratomas-yolk sac tumours of the infantile testis, the …

Determining the origin of uterine adenocarcinomas can be difficult in biopsy and curettage
specimens because the morphologic spectrum of endocervical and endometrial …

The p16 INK 4 aa (CDKN2) tumor suppressor gene is altered in several tumor types, but the
frequency and mechanism of inactivation are largely unknown for endometrial carcinomas …

BACKGROUND Endometrial carcinomas seem to carry a different prognosis depending on
the presence or absence of concomitant complex atypical hyperplasia (hyperplasia). The …

Paraffin sections from 190 epithelial ovarian tumours, including 159 malignant and 31
benign epithelial tumours, were analysed immunohistochemically for expression of cyclin …

The roles of the p16 and p15 inhibitor of cyclin-dependent kinase tumour suppressor genes
were examined in human uterine cervical and endometrial cancers. p16 mRNA, examined …