SUMO: from bench to bedside
HM Chang, ETH Yeh - Physiological Reviews, 2020 - journals.physiology.org
Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates
multiple biological processes, including cell division, DNA replication/repair, signal …
multiple biological processes, including cell division, DNA replication/repair, signal …
Function and regulation of SUMO proteases
CM Hickey, NR Wilson, M Hochstrasser - Nature reviews Molecular cell …, 2012 - nature.com
Covalent attachment of small ubiquitin-like modifier (SUMO) to proteins is highly dynamic,
and both SUMO–protein conjugation and cleavage can be regulated. Protein desumoylation …
and both SUMO–protein conjugation and cleavage can be regulated. Protein desumoylation …
NLRs guard metabolism to coordinate pattern-and effector-triggered immunity
K Zhai, DI Liang, H Li, F Jiao, B Yan, J Liu, Z Lei… - Nature, 2022 - nature.com
Pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) in plants enable them
to respond to pathogens by activating the production of defence metabolites that orchestrate …
to respond to pathogens by activating the production of defence metabolites that orchestrate …
Sumoylation: a regulatory protein modification in health and disease
A Flotho, F Melchior - Annual review of biochemistry, 2013 - annualreviews.org
Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now
established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds …
established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds …
SUMO-specific proteases/isopeptidases: SENPs and beyond
SUMO-specific proteases/isopeptidases: SENPs and beyond | Genome Biology Skip to main
content SpringerLink Account Menu Find a journal Publish with us Track your research Search …
content SpringerLink Account Menu Find a journal Publish with us Track your research Search …
Dealing with stress: a review of plant SUMO proteases
R Morrell, A Sadanandom - Frontiers in plant science, 2019 - frontiersin.org
The SUMO system is a rapid dynamic post-translational mechanism employed by eukaryotic
cells to respond to stress. Plant cells experience hyperSUMOylation of substrates in …
cells to respond to stress. Plant cells experience hyperSUMOylation of substrates in …
Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad
AR Buller, CA Townsend - Proceedings of the National …, 2013 - National Acad Sciences
The study of proteolysis lies at the heart of our understanding of biocatalysis, enzyme
evolution, and drug development. To understand the degree of natural variation in protease …
evolution, and drug development. To understand the degree of natural variation in protease …
Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration
AV Luebben, D Bender, S Becker, LM Crowther… - Science …, 2022 - science.org
Genetic CLN5 variants are associated with childhood neurodegeneration and Alzheimer's
disease; however, the molecular function of ceroid lipofuscinosis neuronal protein 5 (Cln5) …
disease; however, the molecular function of ceroid lipofuscinosis neuronal protein 5 (Cln5) …
SUMO conjugation to the pattern recognition receptor FLS2 triggers intracellular signalling in plant innate immunity
Detection of conserved microbial patterns by host cell surface pattern recognition receptors
(PRRs) activates innate immunity. The FLAGELLIN-SENSITIVE 2 (FLS2) receptor perceives …
(PRRs) activates innate immunity. The FLAGELLIN-SENSITIVE 2 (FLS2) receptor perceives …
Identification and classification of papain-like cysteine proteinases
F Ozhelvaci, K Steczkiewicz - Journal of Biological Chemistry, 2023 - ASBMB
Papain-like cysteine peptidases form a big and highly diverse superfamily of proteins
involved in many important biological functions, such as protein turnover, deubiquitination …
involved in many important biological functions, such as protein turnover, deubiquitination …