Neutrophils in acute inflammation: current concepts and translational implications

A Margraf, CA Lowell, A Zarbock - Blood, The Journal of the …, 2022 - ashpublications.org
Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to
sites of infection to combat invading pathogens while, at the same time, limiting host tissue …

Neutrophil‐T cell crosstalk and the control of the host inflammatory response

S Bert, S Nadkarni, M Perretti - Immunological reviews, 2023 - Wiley Online Library
While fundamental in their innate role in combating infection and responding to injury,
neutrophils are emerging as key modulators of adaptive immune responses. Such functions …

Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow

M Lad, AS Beniwal, S Jain, P Shukla, V Kalistratova… - Cancer Cell, 2024 - cell.com
Tumor-associated neutrophil (TAN) effects on glioblastoma (GBM) biology remain under-
characterized. We show here that neutrophils with dendritic features—including …

Neutrophils in pregnancy: New insights into innate and adaptive immune regulation

S Bert, EJ Ward, S Nadkarni - Immunology, 2021 - Wiley Online Library
The immunology of pregnancy has been the focus of many studies to better understand how
the mother is able to tolerate the presence of a semi‐allogeneic fetus. Far from the initial …

Tumor-mediated neutrophil polarization and therapeutic implications

S Raftopoulou, P Valadez-Cosmes, ZN Mihalic… - International Journal of …, 2022 - mdpi.com
Neutrophils are immune cells with reported phenotypic and functional plasticity. Tumor-
associated neutrophils display many roles during cancer progression. Several tumor …

Neutrophils in inflammatory diseases: Unraveling the impact of their derived molecules and heterogeneity

B Riaz, S Sohn - Cells, 2023 - mdpi.com
Inflammatory diseases involve numerous disorders and medical conditions defined by an
insufficient level of self-tolerance. These diseases evolve over the course of a multi-step …

Autonomous IL-36R signaling in neutrophils activates potent antitumor effector functions

S Roy, K Fitzgerald, A Lalani, CW Lai… - The Journal of …, 2023 - Am Soc Clin Investig
While the rapid advancement of immunotherapies has revolutionized cancer treatment, only
a small fraction of patients derive clinical benefit. Eradication of large, established tumors …

Differential functional responses of neutrophil subsets in severe COVID-19 patients

KR McLeish, R Shrestha, A Vashishta… - Frontiers in …, 2022 - frontiersin.org
Neutrophils play a significant role in determining disease severity following SARS-CoV-2
infection. Gene and protein expression defines several neutrophil clusters in COVID-19 …

Neutrophils: Musketeers against immunotherapy

KR Zahid, U Raza, S Tumbath, L Jiang, W Xu… - Frontiers in …, 2022 - frontiersin.org
Neutrophils, the most copious leukocytes in human blood, play a critical role in
tumorigenesis, cancer progression, and immune suppression. Recently, neutrophils have …

Neutrophils at the crossroads: unraveling the multifaceted role in the tumor microenvironment

D Awasthi, A Sarode - International Journal of Molecular Sciences, 2024 - mdpi.com
Over the past decade, research has prominently established neutrophils as key contributors
to the intricate landscape of tumor immune biology. As polymorphonuclear granulocytes …