[HTML][HTML] The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation

A Plotnikov, E Zehorai, S Procaccia, R Seger - Biochimica et Biophysica …, 2011 - Elsevier
The MAPK cascades are central signaling pathways that regulate a wide variety of
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …

[HTML][HTML] Nuclear ERK: mechanism of translocation, substrates, and role in cancer

G Maik-Rachline, A Hacohen-Lev-Ran… - International journal of …, 2019 - mdpi.com
The extracellular signal-regulated kinases 1/2 (ERK) are central signaling components that
regulate stimulated cellular processes such as proliferation and differentiation. When …

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

Y Mebratu, Y Tesfaigzi - Cell cycle, 2009 - Taylor & Francis
Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-
activated protein kinase super family that can mediate cell proliferation and apoptosis. The …

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

S Yoon, R Seger - Growth factors, 2006 - Taylor & Francis
The extracellular signal-regulated kinase (ERK) cascade is a central pathway that transmits
signals from many extracellular agents to regulate cellular processes such as proliferation …

[HTML][HTML] The MEK/ERK cascade: from signaling specificity to diverse functions

YD Shaul, R Seger - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2007 - Elsevier
The ERK signaling cascade is a central MAPK pathway that plays a role in the regulation of
various cellular processes such as proliferation, differentiation, development, learning …

Signal transduction through MAP kinase cascades

TS Lewis, PS Shapiro, NG Ahn - Advances in cancer research, 1998 - Elsevier
Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

Mitogen-activated protein kinases: specific messages from ubiquitous messengers

HJ Schaeffer, MJ Weber - Molecular and cellular biology, 1999 - Am Soc Microbiol
Signal transduction networks allow cells to perceive changes in the extracellular
environment and to mount an appropriate response. Mitogen-activated protein kinase …

Extracellular-regulated kinases: signaling from Ras to ERK substrates to control biological outcomes

ST Eblen - Advances in cancer research, 2018 - Elsevier
The extracellular-regulated kinases ERK1 and ERK2 are evolutionarily conserved,
ubiquitous serine–threonine kinases that are involved in regulating cellular signaling in both …

MAP Kinase Pathways in the YeastSaccharomyces cerevisiae

MC Gustin, J Albertyn, M Alexander… - … and Molecular biology …, 1998 - Am Soc Microbiol
SUMMARY A cascade of three protein kinases known as a mitogen-activated protein kinase
(MAPK) cascade is commonly found as part of the signaling pathways in eukaryotic cells …

Mapk signalling: Erk5 versus erk1/2

S Nishimoto, E Nishida - EMBO reports, 2006 - embopress.org
Extracellular‐signal‐regulated kinase 5 (ERK5) is a member of the mitogen‐activated
protein kinase (MAPK) family and, similar to ERK1/2, has the Thr–Glu–Tyr (TEY) activation …