Neurons are highly specialized cells whose connectivity at synapses subserves rapid
information transfer in the brain. Proper information processing, learning, and memory …

Exosomes, a type of small extracellular vesicles (sEVs), are secreted membrane vesicles
that are derived from various cell types, including cancer cells, mesenchymal stem cells, and …

Exosomes, a type of small extracellular vesicles (sEVs), derived from multivesicular bodies
(MVBs), mediate cell-to-cell communication by transporting proteins, mRNAs, and miRNAs …

Synaptic plasticity represents the long lasting activity-related strengthening or weakening of
synaptic transmission, whose well-characterized types are the long term potentiation and …

The endoplasmic reticulum (ER)-associated degradation (ERAD) pathway in the yeast
Saccharomyces cerevisiae is mediated by two membrane-bound ubiquitin ligases, Doa10 …

Misfolded proteins in the endoplasmic reticulum (ER) are degraded by ER-associated
degradation (ERAD). Although ERAD components involved in degradation of luminal …

TP53 mutations are prevalent in various cancers, yet the complexity of apoptotic pathway
deregulation suggests the involvement of additional factors. HOPS/TMUB1 is known to …

Apoptotic signalling by p53 occurs at both transcriptional and non‐transcriptional levels, as
p53 may act as a direct apoptogenic stimulus via activation of the intrinsic mitochondrial …

Ubiquitin-mediated endocytosis and post-endocytic trafficking of glutamate receptors control
their synaptic abundance and are implicated in modulating synaptic strength. Ubiquitination …

HOPS/Tmub1 is a ubiquitously expressed transmembrane ubiquitin-like protein that shuttles
between nucleus and cytoplasm during cell cycle progression. HOPS causes cell cycle …