Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …

Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …

IL-2 was first identified as a growth factor capable of driving the expansion of activated
human T cell populations. In the more than 40 years since its discovery, a tremendous …

Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in
signal transduction initiated by a wide range of membrane receptors. Among the proteins in …

Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …

Interleukin-2 (IL-2) is a pleiotropic cytokine that drives T-cell growth, augments NK cytolytic
activity, induces the differentiation of regulatory T cells, and mediates activation-induced cell …

Simple Summary Emerging knowledge of the two type I cytokine family members IL-2 and IL-
15 has led to critical therapeutic implications for cancer treatment. Here we discuss the …

▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …

Ten years have passed since the molecular cloning of interleukin 6 (IL-6) in 1986. IL-6 is a
typical cytokine, exhibiting functional pleiotropy and redundancy. IL-6 is involved in the …

Summary Interleukin‐15 (IL‐15) exerts many biological functions essential for the
maintenance and function of multiple cell types. Although its expression is tightly regulated …