Nutritional immunity: the battle for nutrient metals at the host–pathogen interface

CC Murdoch, EP Skaar - Nature Reviews Microbiology, 2022 - nature.com
Trace metals are essential micronutrients required for survival across all kingdoms of life.
From bacteria to animals, metals have critical roles as both structural and catalytic cofactors …

TonB-dependent transport across the bacterial outer membrane

A Silale, B van den Berg - Annual Review of Microbiology, 2023 - annualreviews.org
TonB-dependent transporters (TBDTs) are present in all gram-negative bacteria and
mediate energy-dependent uptake of molecules that are too scarce or large to be taken up …

Deciphering the virulence factors, regulation, and immune response to Acinetobacter baumannii infection

A Shadan, A Pathak, Y Ma, R Pathania… - Frontiers in Cellular and …, 2023 - frontiersin.org
Deciphering the virulence factors, regulation, and immune response to Acinetobacter
baumannii infection Acinetobacter baumannii is a gram-negative multidrug-resistant …

[HTML][HTML] The role of quorum sensing, biofilm formation, and iron acquisition as key virulence mechanisms in Acinetobacter baumannii and the corresponding anti …

SKK Law, HS Tan - Microbiological Research, 2022 - Elsevier
Acinetobacter baumannii is a nosocomial pathogen responsible for several serious
infections, including pneumonia, sepsis, and meningitis. The propensity of this bacterium to …

Pathogenicity and virulence of Acinetobacter baumannii: Factors contributing to the fitness in healthcare settings and the infected host

M Lucidi, D Visaggio, A Migliaccio, G Capecchi… - Virulence, 2024 - Taylor & Francis
Acinetobacter baumannii is a common cause of healthcare-associated infections and
hospital outbreaks, particularly in intensive care units. Much of the success of A. baumannii …

Pan-Genome Plasticity and Virulence Factors: A Natural Treasure Trove for Acinetobacter baumannii

T Karampatakis, K Tsergouli, P Behzadi - Antibiotics, 2024 - mdpi.com
Acinetobacter baumannii is a Gram-negative pathogen responsible for a variety of
community-and hospital-acquired infections. It is recognized as a life-threatening pathogen …

Biosynthesis, acquisition, regulation, and upcycling of heme: recent advances

F Yu, Z Wang, Z Zhang, J Zhou, J Li… - Critical Reviews in …, 2024 - Taylor & Francis
Heme, an iron-containing tetrapyrrole in hemoproteins, including: hemoglobin, myoglobin,
catalase, cytochrome c, and cytochrome P450, plays critical physiological roles in different …

Genomics of Acinetobacter baumannii iron uptake

I Artuso, H Poddar, BA Evans… - Microbial …, 2023 - microbiologyresearch.org
Iron is essential for growth in most bacteria due to its redox activity and its role in essential
metabolic reactions; it is a cofactor for many bacterial enzymes. The bacterium Acinetobacter …

Iron acquisition mechanisms and their role in the virulence of Acinetobacter baumannii

S Cook-Libin, EME Sykes, V Kornelsen… - Infection and …, 2022 - Am Soc Microbiol
Iron is an essential element for survival of most organisms. One mechanism of host defense
is to tightly chelate iron to several proteins to limit its extracellular availability. This has forced …

Structure of heme-binding pocket in heme protein is generally rigid and can be predicted by AlphaFold2

HX Kondo, Y Kanematsu, Y Takano - Chemistry Letters, 2022 - academic.oup.com
AlphaFold2 is a deep-learning algorithm used to predict the tertiary structures of proteins
based on their amino acid sequences. We examined whether AlphaFold2 could predict the …