Rationale: The progressive disruption of extracellular matrix (ECM) proteins, particularly
early elastin fragmentation followed by abnormalities in collagen fibril organization, are key …

Aortic dissection and rupture are triggered by decreased vascular wall strength and/or
increased mechanical loads. We investigated the role of mTOR signaling in aortopathy …

Background Abdominal aortic aneurysm (AAA), a degenerative vascular pathology
characterized by permanent dilation of the aorta, is considered a chronic inflammatory …

Chronic infusion of angiotensin-II in atheroprone (ApoE−/−) mice provides a reproducible
model of dissection in the suprarenal abdominal aorta, often with a false lumen and …

Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease with an up to 80%
mortality in case of rupture. Current biomarkers fail to account for size-independent risk of …

The cleavage of osteopontin (OPN) by thrombin results in an N-terminal fragment (OPN-N),
which exposes a cryptic integrin-binding motif that promotes the adherence of cells, and …

Aims Abdominal aortic aneurysm (AAA) is a common, serious vascular disease with no
effective pharmacological treatment. The nucleoside adenosine plays an important role in …

Abdominal aortic aneurysm (AAA) is a prevalent aortic disease that causes high mortality
due to asymptomatic gradual expansion and sudden rupture. The underlying molecular …

Animal models of aortic aneurysm and dissection can enhance our limited understanding of
the etiology of these lethal conditions particularly because early-stage longitudinal data are …

Background Mouse models of abdominal aortic aneurysm (AAA) and dissection have
proven to be invaluable in the advancement of diagnostics and therapeutics by providing a …