To exist in a wide range of environmental niches, bacteria must sense and respond to a
variety of external signals. A primary means by which this occurs is through two-component …

Recent advances in high-throughput methods have provided us with a first glimpse of the
overall structure of molecular interaction networks in biological systems. Ultimately, we …

We are beginning to elucidate transcriptional regulatory networks on a large scale and to
understand some of the structural principles of these networks,, but the evolutionary …

The sifting and winnowing of DNA sequence that occur during evolution cause
nonfunctional sequences to diverge, leaving phylogenetic footprints of functional sequence …

The most detailed information presently available for an organism's transcriptional
regulation network is that for the prokaryote Escherichia coli. In order to gain insight into the …

Transcription factors (TFs) play key roles in both development and stress responses. By
integrating into and rewiring original systems, novel TFs contribute significantly to the …

Transcription is an essential step in gene expression and its understanding has been one of
the major interests in molecular and cellular biology. By precisely tuning gene expression …

The structure of complex transcriptional regulatory networks has been studied extensively in
certain model organisms. However, the evolutionary dynamics of these networks across …

A central problem in the bioinformatics of gene regulation is to find the binding sites for
regulatory proteins. One of the most promising approaches toward identifying these short …

SUMMARY A major part of organismal complexity and versatility of prokaryotes resides in
their ability to fine-tune gene expression to adequately respond to internal and external …