Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …

The endosomal-lysosomal system is made up of a set of intracellular membranous
compartments that dynamically interconvert, which is comprised of early endosomes …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor
genetically linked to the risk for Alzheimer's disease (AD). A proteolytic product, soluble …

The amyloid β peptide (Aβ) is a critical initiator that triggers the progression of Alzheimer's
Disease (AD) via accumulation and aggregation, of which the process may be caused by Aβ …

The endosomal network comprises an interconnected network of membranous
compartments whose primary function is to receive, dissociate, and sort cargo that originates …

The retromer complex is a vital element of the endosomal protein sorting machinery that is
conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …

Phagocytosis controls CNS homeostasis by facilitating the removal of unwanted cellular
debris. Accordingly, impairments in different receptors or proteins involved in phagocytosis …

Summary Vacuolar protein sorting-35 (VPS35) is a retromer component for endosomal
trafficking. Mutations of VPS35 have been linked to familial Parkinson's disease (PD). Here …

Endosomes are dynamic intracellular compartments that control the sorting of a constant
stream of different transmembrane cargos either for ESCRT‐mediated degradation or for …

Vacuolar protein sorting-35 (VPS35) is essential for endosome-to-Golgi retrieval of
membrane proteins. Mutations in the VPS35 gene have been identified in patients with …