Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …

Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Matrix metalloproteinases have long been associated with cancer. Clinical trials of small
molecule inhibitors for this family of enzymes however, were spectacularly unsuccessful in a …

Microvesicles are generated by the outward budding and fission of membrane vesicles from
the cell surface. Recent studies suggest that microvesicle shedding is a highly regulated …

Rationale The structural and functional integrity of the endothelium is crucial in maintaining
vascular homeostasis and preventing atherosclerosis. Patients with systemic lupus …

Background Increased mitogen-activated protein kinase (MAPK) signaling, small GTPase
activation, cytoskeletal rearrangements, and the directed targeting of proteases to sites of …

Extracellular vesicles (EVs) are membrane enclosed micro-and nano-sized vesicles that are
secreted from almost every species, ranging from prokaryotes to eukaryotes, and from …

Extracellular vesicles (EVs) are membrane-enveloped nanoscale particles that carry various
bioactive signaling molecules secreted by cells. Their biological roles depend on the …

Extracellular vesicles (EV) are small plasma membrane-derived particles released into the
extracellular space by virtually all cell types. Recently, EV have received increased interest …