Neurodegenerative disorders represent a major and growing healthcare challenge globally.
Among the numerous molecular pathways implicated in their pathogenesis, calpain …

Autophagy is a fundamental homeostatic pathway that mediates the degradation and
recycling of intracellular components. It serves as a key quality control mechanism …

This review postulates that age-related neurodegeneration entails inappropriate activation
of intrinsic pathways to enable brain plasticity through deregulated calcium (Ca2+) …

Organophosphate (OP) poisoning can trigger cholinergic crisis, a life-threatening toxidrome
that includes seizures and status epilepticus. These acute toxic responses are associated …

Tau, a microtubule-associated protein predominantly localized in neuronal axons, plays a
crucial role in promoting microtubule assembly, stabilizing their structure, and participating …

Polygala tenuifolia was documented to calm the mind and promote wisdom. However, its
underlying mechanisms are still unclear. This study aimed to investigate the mechanisms …

Neurodegenerative diseases are a group of diseases characterized by the progressive loss
of neurons, including Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral …

Cyclin-dependent kinases 5 (Cdk5) is a special member of proline-directed serine threonine
kinase family. Unlike other Cdks, Cdk5 is not directly involved in cell cycle regulation but …

Calpains are a class of non-lysosomal cysteine proteases that exert their regulatory
functions via limited proteolysis of their substrates. Similar to the lysosomal and proteasomal …

Calpain activation has been implicated in various pathologies, including
neurodegeneration. Thus, calpain inhibition could effectively prevent spinal cord injury (SCI) …