Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron (MN) disease. Its primary
cause remains elusive, although a combination of different causal factors cannot be ruled …

Neuroinflammation is a hallmark of neurodegenerative diseases including Alzheimer's
disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Microglia …

Importance Amyotrophic lateral sclerosis (ALS) has an immune component, but previous
human studies have not examined immune changes over time. Objectives To assess …

Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease
affecting primarily the upper and lower motor neurons. A common feature of all ALS cases is …

Objective To identify dysregulated metabolic pathways in amyotrophic lateral sclerosis (ALS)
versus control participants through untargeted metabolomics. Methods Untargeted …

NK cells are innate immune cells implicated in ALS; whether NK cells impact ALS in a sex-
and age-specific manner was investigated. Herein, NK cells were depleted in male and …

Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative
disease. Despite decades of research and many new insights into disease biology over the …

Objective To determine whether neutrophils contribute to amyotrophic lateral sclerosis (ALS)
progression, we tested the association of baseline neutrophil count on ALS survival, whether …

Background and purpose The objective was to assess the ability of eight commonly
measured blood markers to serve as prognostic biomarkers in amyotrophic lateral sclerosis …

Introduction: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of cortical,
brainstem, and spinal motor neurons; it causes progressive muscle weakness and atrophy …