Drug resistance in influenza A virus: the epidemiology and management

M Hussain, HD Galvin, TY Haw… - Infection and drug …, 2017 - Taylor & Francis
Influenza A virus (IAV) is the sole cause of the unpredictable influenza pandemics and
deadly zoonotic outbreaks and constitutes at least half of the cause of regular annual …

Lipid–protein interactions in virus assembly and budding from the host cell plasma membrane

BB Motsa, RV Stahelin - Biochemical Society Transactions, 2021 - portlandpress.com
Lipid enveloped viruses contain a lipid bilayer coat that protects their genome to help
facilitate entry into the new host cell. This lipid bilayer comes from the host cell which they …

Reverse vaccinology approach to design a novel multi-epitope subunit vaccine against avian influenza A (H7N9) virus

M Hasan, PP Ghosh, KF Azim, S Mukta, RA Abir… - Microbial …, 2019 - Elsevier
H7N9, a novel strain of avian origin influenza was the first recorded incidence where a
human was transited by a N9 type influenza virus. Effective vaccination against influenza A …

Influenza A matrix protein M1 multimerizes upon binding to lipid membranes

M Hilsch, B Goldenbogen, C Sieben, CT Höfer… - Biophysical journal, 2014 - cell.com
The matrix protein M1 plays a pivotal role in the budding of influenza virus from the plasma
membrane (PM) of infected cells. This protein interacts with viral genetic material and …

[HTML][HTML] Insight into the first multi-epitope-based peptide subunit vaccine against avian influenza A virus (H5N6): an immunoinformatics approach

MM Mia, M Hasan, S Ahmed, MN Rahman - Infection, Genetics and …, 2022 - Elsevier
The rampant spread of highly pathogenic avian influenza A (H5N6) virus has drawn
additional concerns along with ongoing Covid-19 pandemic. Due to its migration-related …

Deep mutational scan of the highly conserved influenza A virus M1 matrix protein reveals substantial intrinsic mutational tolerance

N Hom, L Gentles, JD Bloom, KK Lee - Journal of virology, 2019 - Am Soc Microbiol
Influenza A virus matrix protein M1 is involved in multiple stages of the viral infectious cycle.
Despite its functional importance, our present understanding of this essential viral protein is …

Matrix proteins of enveloped viruses: a case study of Influenza A virus M1 protein

LV Kordyukova, EV Shtykova, LA Baratova… - Journal of …, 2019 - Taylor & Francis
Influenza A virus, a member of the Orthomyxoviridae family of enveloped viruses, is one of
the human and animal top killers, and its structure and components are therefore extensively …

Mutations in the influenza A virus M1 protein enhance virus budding to complement lethal mutations in the M2 cytoplasmic tail

H Liu, ML Grantham, A Pekosz - Journal of virology, 2018 - Am Soc Microbiol
The influenza A virus M1 and M2 proteins play important roles in virus assembly and in the
morphology of virus particles. Mutations in the distal cytoplasmic tail region of M2, and in …

Influenza virus Matrix Protein M1 preserves its conformation with pH, changing multimerization state at the priming stage due to electrostatics

EV Shtykova, LA Dadinova, NV Fedorova… - Scientific reports, 2017 - nature.com
Influenza A virus matrix protein M1 plays an essential role in the virus lifecycle, but its
functional and structural properties are not entirely defined. Here we employed small-angle …

pH-dependent formation and disintegration of the influenza A virus protein scaffold to provide tension for membrane fusion

OV Batishchev, LA Shilova, MV Kachala… - Journal of …, 2016 - Am Soc Microbiol
Influenza virus is taken up from a pH-neutral extracellular milieu into an endosome, whose
contents then acidify, causing changes in the viral matrix protein (M1) that coats the inner …