Low-molecular-weight vascular-disrupting agents (VDAs) cause a pronounced shutdown in
blood flow to solid tumours, resulting in extensive tumour-cell necrosis, while they leave the …

Purpose: The Cancer Imaging Program of the National Cancer Institute convened a
workshop to assess the current status of hypoxia imaging, to assess what is known about the …

Glioma has been considered resistant to chemotherapy and radiation. Recently,
concomitant and adjuvant chemoradiotherapy with temozolomide has become the standard …

Nitric oxide (NO) is a pleiotropic molecule critical to a number of physiological and
pathological processes. The last decade has witnessed major advances in dissecting NO …

The presence of multiple areas of hypoxia (low oxygen tension) is a hallmark feature of
human and experimental tumors. Monocytes are continually recruited into tumors …

Quercetin is a unique dietary polyphenol because it can exert biphasic dose-responses on
cells depending on its concentration. Cancer preventative effects of quercetin are observed …

Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical
outcome. The significance of hypoxia in the development of resistance to radiotherapy has …

Glioblastoma, the most frequent and aggressive malignant brain tumor, has a very poor
prognosis of approximately 1-year. The associated aggressive phenotype and therapeutic …

A functional vascular supply is critical for the continued growth and development of solid
tumors. It also plays a major role in metastatic spread of tumor cells. This importance has led …

Colchicine, the main alkaloid of the poisonous plant meadow saffron (Colchicum autumnale
L.), is a classical drug used for the treatment of gout and familial Mediterranean fever …