The germinal centre B cell response to SARS-CoV-2

BJ Laidlaw, AH Ellebedy - Nature Reviews Immunology, 2022 - nature.com
The germinal centre (GC) response is critical for the generation of affinity-matured plasma
cells and memory B cells capable of mediating long-term protective immunity …

Antibody-mediated neutralization of SARS-CoV-2

H Gruell, K Vanshylla, T Weber, CO Barnes, C Kreer… - Immunity, 2022 - cell.com
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …

Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent …

S Sheikh-Mohamed, B Isho, GYC Chao, M Zuo… - Mucosal …, 2022 - nature.com
Although SARS-CoV-2 infects the upper respiratory tract, we know little about the amount,
type, and kinetics of antibodies (Ab) generated in the oral cavity in response to COVID-19 …

[HTML][HTML] Mucosal immune response in BNT162b2 COVID-19 vaccine recipients

L Azzi, D Dalla Gasperina, G Veronesi, M Shallak… - …, 2022 - thelancet.com
Background Although the BNT162b2 COVID-19 vaccine is known to induce IgG neutralizing
antibodies in serum protecting against COVID-19, it has not been studied in detail whether it …

Prevention of host-to-host transmission by SARS-CoV-2 vaccines

D Mostaghimi, CN Valdez, HT Larson… - The Lancet infectious …, 2022 - thelancet.com
As the number of individuals vaccinated against SARS-CoV-2 rises worldwide, population-
level data regarding the vaccines' ability to reduce infection are being generated …

Mucosal vaccines, sterilizing immunity, and the future of SARS-CoV-2 virulence

D Focosi, F Maggi, A Casadevall - Viruses, 2022 - mdpi.com
Sterilizing immunity after vaccination is desirable to prevent the spread of infection from
vaccinees, which can be especially dangerous in hospital settings while managing frail …

Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy

ZL Brumme, F Mwimanzi, HR Lapointe, PK Cheung… - npj Vaccines, 2022 - nature.com
Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain
incompletely characterized. We measured circulating antibodies against the SARS-CoV-2 …

Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination

TG Caniels, I Bontjer, K van der Straten, M Poniman… - Science …, 2021 - science.org
Emerging SARS-CoV-2 variants of concern (VOCs) pose a threat to human immunity
induced by natural infection and vaccination. We assessed the recognition of three VOCs (B …

The mucosal and serological immune responses to the novel coronavirus (SARS-CoV-2) vaccines

RWY Chan, S Liu, JY Cheung, JGS Tsun… - Frontiers in …, 2021 - frontiersin.org
Background Although the serological antibody responses induced by SARS-CoV-2 vaccines
are well characterized, little is known about their ability to elicit mucosal immunity. Objectives …

Highly specific memory B cells generation after the 2nd dose of BNT162b2 vaccine compensate for the decline of serum antibodies and absence of mucosal IgA

E Piano Mortari, C Russo, MR Vinci, S Terreri… - Cells, 2021 - mdpi.com
Specific memory B cells and antibodies are a reliable read-out of vaccine efficacy. We
analysed these biomarkers after one and two doses of BNT162b2 vaccine. The second dose …