BACKGROUND: Traditional cancer therapy can be successful in destroying tumors, but can
also cause dangerous side effects. Therefore, many targeted therapies are in development …

Current cancer management strategies fail to adequately treat malignancies with
multivariable dose-restricting factors such as systemic toxicity and multi-drug resistance …

Many drug targets are localized to particular subcellular compartments, yet current drug
design strategies are focused on bioavailability and tissue targeting and rarely address drug …

Traditional anti-cancer treatments consist of chemotherapeutic drugs that effectively
eliminate rapidly dividing tumor cells. However, in many cases chemotherapy fails to …

Hepatocellular carcinoma (HCC) has a fairly high morbidity and is notoriously difficult to treat
due to long latent period before detection, multidrug resistance and severe drug-related …

Transferrin (Trf) is a highly conserved serum glycoprotein mostly known for its iron transport
capacity. As iron is an indispensable nutrient for cell division, Trf and its receptor have long …

Cancer cells frequently upregulate surface receptors that promote growth and survival.
These receptors constitute valid targets for intervention. One strategy involves the delivery of …

The goal of drug delivery is to improve the safety and therapeutic efficacy of drugs. This
review focuses on delivery platforms that are either derived from endogenous pathways …

It has been 20 years since the publication of Chemistry of Protein Conjugation and Cross-
Linking. During this period, great advances have been made in the area of cross-linking of …

One of the major drawbacks of many of the currently used cancer drugs are off-target effects.
Targeted delivery is one method to minimize such unwanted and detrimental events. To …