Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression

S Sui, S Xu, D Pang - Pharmacology & therapeutics, 2022 - Elsevier
Breast cancer has become a serious threat to women's health. Cancer progression is mainly
derived from resistance to apoptosis induced by procedures or therapies. Therefore, new …

Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling

SC Koeberle, AP Kipp, H Stuppner… - Medicinal Research …, 2023 - Wiley Online Library
Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid
peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight …

Senolytics and senostatics as adjuvant tumour therapy

S Short, E Fielder, S Miwa, T von Zglinicki - EBioMedicine, 2019 - thelancet.com
Cell senescence is a driver of ageing, frailty, age-associated disease and functional decline.
In oncology, tumour cell senescence may contribute to the effect of adjuvant therapies, as it …

Metabolism and immunity in breast cancer

D Zhang, X Xu, Q Ye - Frontiers of medicine, 2021 - Springer
Breast cancer is one of the most common malignancies that seriously threaten women's
health. In the process of the malignant transformation of breast cancer, metabolic …

[HTML][HTML] Autophagy-related long non-coding RNA signature for potential prognostic biomarkers of patients with cervical cancer: a study based on public databases

Q Feng, J Wang, N Cui, X Liu… - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
Background Metastasis and recurrence are the main causes of death from cervical cancer
(CC), thus it is important to identify more effective biomarkers to improve its prognosis. The …

Development of a clinical prognostic model for metabolism‐related genes in squamous lung cancer and correlation analysis of immune microenvironment

Z Zhuang, C Gao - BioMed Research International, 2022 - Wiley Online Library
Background. The incidence of squamous lung cancer (LUSC) has substantially increased.
Systematic studies of metabolic genomic patterns are fundamental for the treatment and …

[HTML][HTML] Non-genetic heterogeneity and immune subtyping in breast cancer: Implications for immunotherapy and targeted therapeutics

M Hassan, L Tutar, D Sari-Ak, A Rasul, E Basheer… - Translational …, 2024 - Elsevier
Breast cancer (BC) is a complex and multifactorial disease, driven by genetic alterations that
promote tumor growth and progression. However, recent research has highlighted the …

Myc upregulates Ggct, γ‐glutamylcyclotransferase to promote development of p53‐deficient osteosarcoma

T Ueno, S Otani, Y Date, Y Katsuma… - Cancer …, 2024 - Wiley Online Library
Osteosarcoma (OS) in humans is characterized by alterations in the TP53 gene. In mice,
loss of p53 triggers OS development, for which c‐Myc (Myc) oncogenicity is indispensable …

MiR-205-5p/GGCT attenuates growth and metastasis of papillary thyroid cancer by regulating CD44

HN Li, HM Zhang, XR Li, J Wang, T Xu, SY Li… - …, 2022 - academic.oup.com
Papillary thyroid cancer (PTC) remains the most common endocrine malignancy, despite
marked achieves in recent decades, and the mechanisms underlying the pathogenesis and …

Synthetic RNA therapeutics in cancer

Y Han, SH Shin, CG Lim, YH Heo, IY Choi… - Journal of Pharmacology …, 2023 - ASPET
Recent advances in the RNA delivery system have facilitated the development of a separate
field of RNA therapeutics, with modalities including mRNA, microRNA (miRNA), antisense …