DP1, a multifaceted synthetic peptide: Mechanism of action, activity and clinical potential

M Maan, H Goyal, S Joshi, P Barman, S Sharma… - Life Sciences, 2024 - Elsevier
Aims Microbial infections remain a leading cause of mortality worldwide, with
Staphylococcus aureus (S. aureus) being a prominent etiological agent, responsible for …

In Vivo Acute Toxicity and Therapeutic Potential of a Synthetic Peptide, DP1 in a Staphylococcus aureus Infected Murine Wound Excision Model

P Barman, C Sharma, S Joshi, S Sharma… - Probiotics and …, 2023 - Springer
Bacterial infections at the surgical sites are one of the most prevalent skin infections that
impair the healing mechanism. They account for about 20% of all types of infections and …

Peptide-reduced graphene oxide based functional paint: A sustainable alternative to toxic biocides

S Joshi, D Sharma, A Saini, G Verma - Progress in Organic Coatings, 2024 - Elsevier
In this study, a sustainable nanoformulation as an antibacterial additive for acrylic wall paint
was developed and tested. The nanoformulation was synthesized by coupling reduced …

Synthetic peptide (DP1) functionalized graphene oxide: A biocompatible nanoformulation with broad-spectrum antibacterial and antibiofilm activity

S Joshi, J Chadha, K Harjai, G Verma, A Saini - FlatChem, 2024 - Elsevier
In the present scenario, clinical success of all existing antimicrobial regimes has been
severely challenged by bacterial infections and emergence of multidrug-resistant strains …

Development of protease resistant and non-cytotoxic Jelleine analogs with enhanced broad spectrum antimicrobial efficacy

T Sarkar, SR Vignesh, T Sehgal, KR Ronima… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Short systemic half-life of Antimicrobial Peptides (AMP) is one of the major bottlenecks that
limits their successful commercialization as therapeutics. In this work, we have designed …

CATH-2-derived antimicrobial peptide inhibits multidrug-resistant Escherichia coli infection in chickens

S Hao, W Shi, L Chen, T Kong, B Wang… - Frontiers in Cellular …, 2024 - frontiersin.org
Avian colibacillosis (AC), caused by infection with Escherichia coli (E. coli), is a major threat
to poultry health, food safety and public health, and results in high mortality and significant …

[HTML][HTML] Design and Evaluation of a Novel Anti-microbial Peptide from Cathelicidin-2: Selectively Active Against Acinetobacter baumannii

F Fathi, M Ghobeh, FH Shirazi… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
Background Infections caused by pathogenic microorganisms have increased the need for
hospital care and have thus represented a public health problem and a significant financial …