Lasso peptides are a large and sequence-diverse class of ribosomally synthesized and post-
translationally modified peptide (RiPP) natural products characterized by their slip knot-like …

Bacteriocins are potent antimicrobial peptides that are produced by bacteria. Since their
discovery almost a century ago, diverse peptides have been discovered and described, and …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) have received
much attention in recent years because of their promising bioactivities and the portability of …

Advances in genome engineering and associated technologies have reinvigorated natural
products research. Here we highlight the latest developments in the field across the discover …

In contrast to the large body of work on bioactive natural products from individually cultivated
bacteria, the chemistry of environmental microbial communities remains largely elusive …

Antimicrobial resistance remains a significant global threat, driving up mortality rates
worldwide. Ribosomally synthesized and post-translationally modified peptides have …

Aborycin is a type I lasso peptide with a stable interlocked structure, offering a favorable
framework for drug development. The aborycin biosynthetic gene cluster gul from marine …

Lasso peptides are a class of ribosomally synthesized and post-translationally modified
peptides (RiPPs) defined by a macrolactam linkage between the N-terminus and the side …

Cyclophane-containing peptides comprise an important group of macrocyclic peptides with
unique structural properties and pharmaceutical relevance. Darobactin A is a ribosomally …

Antimicrobial resistance remains a significant global threat, contributing significantly to
mortality rates worldwide. Ribosomally synthesized and post-translationally modified …