Overexpression of plasminogen activator inhibitor-1 (SER-PINE1, PAI-1), the major
physiological inhibitor of pericellular plasmin generation, is a significant causative factor in …

Objective—Reactive oxygen species have been implicated as signaling molecules
modulating the activity of redox-sensitive transcription factors such as nuclear factor kappa B …

The oxygen sensitive α-subunit of the hypoxia-inducible factor-1 (HIF-1) is a major trigger of
the cellular response to hypoxia. Although the posttranslational regulation of HIF-1α by …

Plasminogen activator inhibitor-1 (PAI-1) controls the regulation of the fibrinolytic system in
blood by inhibiting both urokinase-type and tissue-type plasminogen activators. Enhanced …

Summary Plasminogen activator inhibitor-1 (PAI-1) paradoxically enhances tumor
progression and angiogenesis; however, the mechanism supporting this role is not known …

Oxygen is vital for the development and survival of mammals. In response to hypoxia, the
brain initiates numerous adaptive responses at the organ level as well as at the molecular …

The upstream stimulatory factor 2 (USF2) is a transcription factor implicated in several
cellular processes and among them, tumor development seems to stand out. However, the …

While the functions of hypoxia-inducible factor 1α (HIF1α)/aryl hydrocarbon receptor nuclear
translocator (ARNT) and HIF2α/ARNT (HIF2) proteins in activating hypoxia-inducible genes …

Pulmonary vascular remodeling associated with pulmonary hypertension is characterized by
media thickening, disordered proliferation, and in situ thrombosis. The p21-activated kinase …

Plasma PAI-1 levels robustly fluctuate in a circadian manner and consequently contribute to
hypofibrinolysis during the early morning. The circadian expression of PAI-1 gene is thought …