Biophysical models of cis-regulation as interpretable neural networks
The adoption of deep learning techniques in genomics has been hindered by the difficulty of
mechanistically interpreting the models that these techniques produce. In recent years, a …
mechanistically interpreting the models that these techniques produce. In recent years, a …
Measuring cis-regulatory energetics in living cells using allelic manifolds
Gene expression in all organisms is controlled by cooperative interactions between DNA-
bound transcription factors (TFs), but quantitatively measuring TF-DNA and TF-TF …
bound transcription factors (TFs), but quantitatively measuring TF-DNA and TF-TF …
[PDF][PDF] The influence of sequence context on the evolution of bacterial gene expression
M Steinrück - 2018 - core.ac.uk
Expression of genes is a fundamental molecular phenotype that is subject to evolution by
different types of mutations. Both the rate and the effect of mutations may depend on the …
different types of mutations. Both the rate and the effect of mutations may depend on the …
The extent of mRNA destabilization and genetic factors of rapid GAP1 mRNA clearance upon a nitrogen upshift.
D Miller - 2018 - search.proquest.com
Cellular responses to changing environments frequently involve rapid transcriptome
reprogramming, and regulated changes in mRNA degradation rates can accelerate this …
reprogramming, and regulated changes in mRNA degradation rates can accelerate this …