Plants have been identified as promising expression systems for commercial production of
vaccine antigens. In phase I clinical trials several plant-derived vaccine antigens have been …

Smallpox has shaped human history, from the earliest human civilizations well into the 20th
century. With high mortality rates, rapid transmission, and serious long-term effects on …

Disease prevention through vaccination is considered to be the greatest contribution to
public health over the past century. Every year more than 100 million children are …

Despite progress in the prevention and treatment of infectious diseases, they continue to
present a major threat to public health. The frequency of emerging and reemerging …

The current diphtheria–tetanus–pertussis (DTP) pediatric vaccine is produced from the
corresponding pathogenic bacteria Corynebacterium diphtheriae, Clostridium tetani and …

Polypeptide variants of the HA1 antigenic domain of the H5N1 avian influenza virus
hemagglutinin (HA) molecule were produced in plants using transient and stable expression …

Mucosal vaccination is a perspective for the control of infectious diseases, since it is capable
of inducing humoral and cell-mediated responses. In addition, the delivery of vaccines to …

Plant systems for the production of recombinant immunogens have the potential to
overcome obstacles currently impeding the delivery of vaccines to poorer, more remote …

The development of new generation vaccines is an imperative tool to counteract accidental
or intended release of bio-threat agents, such as Bacillus anthracis, Yersinia pestis and …

Compositions and methods for producing plant-derived immunogenic compositions that
confer immunity against Smallpox in a subject are provided. Plants engineered to produce …