Gut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target

S Yang, X Li, F Yang, R Zhao, X Pan, J Liang… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular disease (CVD) is the leading cause of death worldwide, especially in
developed countries, and atherosclerosis (AS) is the common pathological basis of many …

Gut microbiota: a new path to treat obesity

G Muscogiuri, E Cantone, S Cassarano… - International journal of …, 2019 - nature.com
Obesity is a multifactorial disease resulting in excessive accumulation of adipose tissue.
Over the last decade, growing evidence has identified the gut microbiota as a potential factor …

The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease

RM Chakaroun, LM Olsson, F Bäckhed - Nature Reviews Cardiology, 2023 - nature.com
Despite milestones in preventive measures and treatment, cardiovascular disease (CVD)
remains associated with a high burden of morbidity and mortality. The protracted nature of …

Role of gut microbiota and their metabolites on atherosclerosis, hypertension and human blood platelet function: a review

AK Duttaroy - Nutrients, 2021 - mdpi.com
Emerging data have demonstrated a strong association between the gut microbiota and the
development of cardiovascular disease (CVD) risk factors such as atherosclerosis …

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease

SH Zeisel, M Warrier - Annual review of nutrition, 2017 - annualreviews.org
Trimethylamine N-oxide (TMAO) is a biologically active molecule and is a putative promoter
of chronic diseases including atherosclerosis in humans. Host intestinal bacteria produce its …

Trimethylamine-N-oxide promotes vascular calcification through activation of NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain …

X Zhang, Y Li, P Yang, X Liu, L Lu, Y Chen… - … , and vascular biology, 2020 - Am Heart Assoc
Objectives: Vascular calcification is highly prevalent in patients with chronic kidney disease.
Increased plasma trimethylamine N-oxide (TMAO), a gut microbiota-dependent product …

The role of gut microbiota in atherosclerosis and hypertension

J Ma, H Li - Frontiers in pharmacology, 2018 - frontiersin.org
In recent years, accumulating evidence has indicated the importance of gut microbiota in
maintaining human health. Gut dysbiosis is associated with the pathogenesis of a number of …

The gut microbiota and its implication in the development of atherosclerosis and related cardiovascular diseases

E Sanchez-Rodriguez, A Egea-Zorrilla, J Plaza-Díaz… - Nutrients, 2020 - mdpi.com
The importance of gut microbiota in health and disease is being highlighted by numerous
research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke …

Trimethylamine N‐oxide generated by the gut microbiota is associated with vascular inflammation: new insights into atherosclerosis

Y Liu, M Dai - Mediators of inflammation, 2020 - Wiley Online Library
Trimethylamine N‐oxide (TMAO) is a biologically active molecule generated by the gut
microbiota. Accumulating evidences have indicated a close association between high …

Circulating trimethylamine N‐oxide and the risk of cardiovascular diseases: a systematic review and meta‐analysis of 11 prospective cohort studies

J Qi, T You, J Li, T Pan, L Xiang… - Journal of cellular and …, 2018 - Wiley Online Library
Circulating trimethylamine N‐oxide (TMAO), a canonical metabolite from gut flora, has been
related to the risk of cardiovascular disorders. However, the association between circulating …