SARS-CoV-2 is the causative agent behind the COVID-19 pandemic, responsible for over
170 million infections, and over 3.7 million deaths worldwide. Efforts to test, treat and …

The N termini of proteins contain information about their biochemical properties and
functions. These N termini can be processed by proteases and can undergo other co-or …

The cellular ability to react to environmental fluctuations depends on signaling networks that
are controlled by the dynamic activities of kinases and phosphatases. Here, to gain insight …

Sexually reproducing eukaryotes employ a developmentally regulated cell division program—
meiosis—to generate haploid gametes from diploid germ cells. To understand how gametes …

ABSTRACT N-terminal protein acetylation is a ubiquitous post-translational modification that
impacts diverse cellular processes in higher organisms. Bacterial proteins are also N …

Melanoma is the leading cause of skin cancer-related deaths, and current melanoma
therapies, including targeted therapies and immunotherapies, benefit only a subset of …

The fidelity of signal transduction requires the binding of regulatory molecules to their
cognate targets. However, the crowded cell interior risks off-target interactions between …

Here we uncover collagen, the main structural protein of all connective tissues, as a redox‐
active material. We identify dihydroxyphenylalanine (DOPA) residues, post‐translational …

Early mammals were nocturnal until the Cretaceous-Paleogene extinction facilitated their
rapid expansion into daytime niches. Diurnality subsequently evolved multiple times …

SARS-CoV-2 is the causative agent behind the COVID-19 pandemic, and responsible for
over 100 million infections, and over 2 million deaths worldwide. Efforts to test, treat and …