Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies
G Limorenko, HA Lashuel - Chemical Society Reviews, 2022 - pubs.rsc.org
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
The emerging role of autophagy and mitophagy in tauopathies: From pathogenesis to translational implications in Alzheimer's disease
X Liu, M Ye, L Ma - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, affecting more
than 55 million individuals worldwide in 2021. In addition to the “amyloid hypothesis”, an …
than 55 million individuals worldwide in 2021. In addition to the “amyloid hypothesis”, an …
Delivery of intravenously administered antibodies targeting alzheimer's disease-relevant tau species into the brain based on receptor-mediated transcytosis
T Tashima - Pharmaceutics, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease that causes memory loss,
cognitive decline, and eventually dementia. The etiology of AD and its pathological …
cognitive decline, and eventually dementia. The etiology of AD and its pathological …
A call for better understanding of target engagement in Tau antibody development
A Bespalov, JP Courade, L Khiroug, GC Terstappen… - Drug Discovery …, 2022 - Elsevier
Highlights•Antibodies have been developed for therapeutic use in several CNS
indications.•Natural barriers need to be passed for antibodies to engage their targets in the …
indications.•Natural barriers need to be passed for antibodies to engage their targets in the …
Analysis of clinical failure of anti-tau and anti-synuclein antibodies in neurodegeneration using a quantitative systems pharmacology model
H Geerts, S Bergeler, M Walker, PH Van der Graaf… - Scientific Reports, 2023 - nature.com
Misfolded proteins in Alzheimer's disease and Parkinson's disease follow a well-defined
connectomics-based spatial progression. Several anti-tau and anti-alpha synuclein (aSyn) …
connectomics-based spatial progression. Several anti-tau and anti-alpha synuclein (aSyn) …
Galectin-3 aggravates microglial activation and tau transmission in tauopathy
Alzheimer's disease is characterized by the accumulation of amyloid-β plaques, aggregation
of hyperphosphorylated tau (pTau), and microglia activation. Galectin-3 (Gal3) is a β …
of hyperphosphorylated tau (pTau), and microglia activation. Galectin-3 (Gal3) is a β …
Current approaches to monitor macromolecules directly from the cerebral interstitial fluid
ML Custers, L Nestor, D De Bundel, A Van Eeckhaut… - Pharmaceutics, 2022 - mdpi.com
Gaining insights into the pharmacokinetic and pharmacodynamic properties of lead
compounds is crucial during drug development processes. When it comes to the treatment of …
compounds is crucial during drug development processes. When it comes to the treatment of …
Self‐Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice
In tauopathy conditions, such as Alzheimer's disease (AD), highly soluble and natively
unfolded tau polymerizes into an insoluble filament; however, the mechanistic details of this …
unfolded tau polymerizes into an insoluble filament; however, the mechanistic details of this …
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry
MJ Ellis, C Lekka, KL Holden, H Tulmin, F Seedat… - Acta …, 2024 - Springer
Antibodies are essential research tools whose performance directly impacts research
conclusions and reproducibility. Owing to its central role in Alzheimer's disease and other …
conclusions and reproducibility. Owing to its central role in Alzheimer's disease and other …
Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review
D Chu, X Yang, J Wang, Y Zhou, JH Gu… - Neural Regeneration …, 2024 - journals.lww.com
Alzheimer's disease is characterized by two major neuropathological hallmarks—the
extracellular β-amyloid plaques and intracellular neurofibrillary tangles consisting of …
extracellular β-amyloid plaques and intracellular neurofibrillary tangles consisting of …