Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan

A Agustí, E Melén, DL DeMeo… - The Lancet …, 2022 - thelancet.com
The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted
disease caused by tobacco smoking in genetically susceptible individuals has been …

Asthma epidemiology and risk factors

J Stern, J Pier, AA Litonjua - Seminars in immunopathology, 2020 - Springer
Asthma is a clinical syndrome that affects all age groups. Asthma prevalence worldwide has
seen a rapid increase in the latter part of the last century. Recent data has shown that …

Impact of air pollution on asthma outcomes

AI Tiotiu, P Novakova, D Nedeva… - International journal of …, 2020 - mdpi.com
Asthma is a chronic respiratory disease characterized by variable airflow obstruction,
bronchial hyperresponsiveness, and airway inflammation. Evidence suggests that air …

Air pollution and DNA methylation: effects of exposure in humans

CF Rider, C Carlsten - Clinical epigenetics, 2019 - Springer
Air pollution exposure is estimated to contribute to approximately seven million early deaths
every year worldwide and more than 3% of disability-adjusted life years lost. Air pollution …

Associations between outdoor air pollutants and non-viral asthma exacerbations and airway inflammatory responses in children and adolescents living in urban areas …

MC Altman, M Kattan, GT O'Connor… - The Lancet Planetary …, 2023 - thelancet.com
Background Asthma prevalence and severity have markedly increased with urbanisation,
and children in low-income urban centres have among the greatest asthma morbidity …

DNA methylation in childhood asthma: an epigenome-wide meta-analysis

CJ Xu, C Söderhäll, M Bustamante, N Baïz… - The lancet Respiratory …, 2018 - thelancet.com
Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …

[HTML][HTML] Epigenome-wide meta-analysis of DNA methylation and childhood asthma

SE Reese, CJ Xu, HT Den Dekker, MK Lee… - Journal of Allergy and …, 2019 - Elsevier
Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …

Epigenetics as a mechanism linking developmental exposures to long-term toxicity

R Barouki, E Melén, Z Herceg, J Beckers, J Chen… - Environment …, 2018 - Elsevier
A variety of experimental and epidemiological studies lend support to the Developmental
Origin of Health and Disease (DOHaD) concept. Yet, the actual mechanisms accounting for …

Prenatal particulate air pollution and DNA methylation in newborns: an epigenome-wide meta-analysis

O Gruzieva, CJ Xu, P Yousefi, C Relton… - Environmental …, 2019 - ehp.niehs.nih.gov
Background: Prenatal exposure to air pollution has been associated with childhood
respiratory disease and other adverse outcomes. Epigenetics is a suggested link between …

The impact of air pollution on skin and related disorders: a comprehensive review

R Abolhasani, F Araghi, M Tabary… - Dermatologic …, 2021 - Wiley Online Library
As the largest organ in the body, human skin is constantly exposed to harmful compounds
existing in the surrounding environment as the first‐line barrier. Studies have indicated that …