The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
Molecular genetics of prostate cancer: new prospects for old challenges
MM Shen, C Abate-Shen - Genes & development, 2010 - genesdev.cshlp.org
Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …
cancer-related mortality and morbidity in men. Since early studies on the role of the …
Prostate cancer reactivates developmental epigenomic programs during metastatic progression
MM Pomerantz, X Qiu, Y Zhu, DY Takeda, W Pan… - Nature …, 2020 - nature.com
Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the
dependency of PCa cells on the androgen receptor (AR), a prostate master transcription …
dependency of PCa cells on the androgen receptor (AR), a prostate master transcription …
The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer …
JM Lucas, C Heinlein, T Kim, SA Hernandez, MS Malik… - Cancer discovery, 2014 - AACR
TMPRSS2 is an androgen-regulated cell-surface serine protease expressed predominantly
in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate …
in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate …
Prostate organogenesis: tissue induction, hormonal regulation and cell type specification
R Toivanen, MM Shen - Development, 2017 - journals.biologists.com
Prostate organogenesis is a complex process that is primarily mediated by the presence of
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …
[HTML][HTML] L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia
The L-type amino acid transporter (LAT) family are Na+-independent transporters, which
deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 …
deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 …
The role of peroxiredoxins in cancer
A Nicolussi, S D'inzeo, C Capalbo… - Molecular and …, 2017 - spandidos-publications.com
Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22‑27 kDa) non‑
seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides …
seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides …
[HTML][HTML] ERβ impedes prostate cancer EMT by destabilizing HIF-1α and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading
P Mak, I Leav, B Pursell, D Bae, X Yang, CA Taglienti… - Cancer cell, 2010 - cell.com
High Gleason grade prostate carcinomas are aggressive, poorly differentiated tumors that
exhibit diminished estrogen receptor β (ERβ) expression. We report that a key function of …
exhibit diminished estrogen receptor β (ERβ) expression. We report that a key function of …
MYC and prostate cancer
Prostate cancer, the majority of which is adenocarcinoma, is the most common epithelial
cancer affecting a majority of elderly men in Western nations. Its manifestation, however …
cancer affecting a majority of elderly men in Western nations. Its manifestation, however …
Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development
Background L-type amino acid transporters (LATs) uptake neutral amino acids including L-
leucine into cells, stimulating mammalian target of rapamycin complex 1 signaling and …
leucine into cells, stimulating mammalian target of rapamycin complex 1 signaling and …