[HTML][HTML] γδ T cells in the tumor microenvironment—Interactions with other immune cells

KF Chan, JDG Duarte, S Ostrouska… - Frontiers in …, 2022 - frontiersin.org
A growing number of studies have shown that γδ T cells play a pivotal role in mediating the
clearance of tumors and pathogen-infected cells with their potent cytotoxic, cytolytic, and …

[HTML][HTML] γδ T cells as a potential therapeutic agent for glioblastoma

I Kang, Y Kim, HK Lee - Frontiers in Immunology, 2023 - frontiersin.org
Although γδ T cells comprise a small population of T cells, they perform important roles in
protecting against infection and suppressing tumors. With their distinct tissue-localizing …

[HTML][HTML] Umbilical cord blood derived cellular therapy: advances in clinical development

J Wang, L Metheny - Frontiers in Oncology, 2023 - frontiersin.org
While cord blood (CB) is primarily utilized in allogeneic hematopoietic cell transplantation
(HCT), the development of novel cell therapy products from CB is a growing and developing …

[HTML][HTML] Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies

A Rao, A Agrawal, G Borthakur… - … for immunotherapy of …, 2024 - ncbi.nlm.nih.gov
Abstract γδ T cells play an important role in disease control in acute myeloid leukemia (AML)
and have become an emerging area of therapeutic interest. These cells represent a minor …

CD277 agonist enhances the immunogenicity of relapsed/refractory acute myeloid leukemia towards Vδ2+ T cell cytotoxicity

T Dong, N Wu, H Gao, S Liang, X Dong, T Zhao… - Annals of …, 2022 - Springer
Relapse and refractoriness remain the major obstacles in clinical treatment of acute myeloid
leukemia (AML). Efficacy of current therapeutic strategies for relapsed/refractory (R/R) AML …

[HTML][HTML] The capability of heterogeneous γδ T cells in cancer treatment

W Yan, LSC Dunmall, NR Lemoine, Y Wang… - Frontiers in …, 2023 - frontiersin.org
γδ T cells, a specialized subset of T lymphocytes, have garnered significant attention within
the realm of cancer immunotherapy. Operating at the nexus between adaptive and innate …

[HTML][HTML] Harnessing unconventional T cells and innate lymphoid cells to prevent and treat hematological Malignancies: prospects for new immunotherapy

A Allegra, M Casciaro, E Lo Presti, C Musolino… - Biomolecules, 2022 - mdpi.com
Unconventional T cells and innate lymphoid cells (ILCs) make up a heterogeneous set of
cells that characteristically show prompt responses toward specific antigens …

[HTML][HTML] γδ T Lymphocytes as a Double-Edged Sword—State of the Art in Gynecological Diseases

A Pawłowska, Y Natochina, W Zardzewiały… - International Journal of …, 2022 - mdpi.com
Human gamma-delta (γδ) T cells are a heterogeneous cell population that bridges the gap
between innate and acquired immunity. They are involved in a variety of immunological …

[HTML][HTML] Directing the migration of serum-free, ex vivo-expanded Vγ9Vδ2 T cells

KK Parwani, GM Branella, RE Burnham… - Frontiers in …, 2024 - frontiersin.org
Vγ9Vδ2 T cells represent a promising cancer therapy platform because the implementation
of allogenic, off-the-shelf product candidates is possible. However, intravenous …

New insights into immune cells in cancer immunotherapy: from epigenetic modification, metabolic modulation to cell communication

S Qin, B Xie, Q Wang, R Yang, J Sun, C Hu, S Liu… - MedComm, 2024 - Wiley Online Library
Cancer is one of the leading causes of death worldwide, and more effective ways of
attacking cancer are being sought. Cancer immunotherapy is a new and effective …