Parkinson's disease (PD) is the most common movement disorder with motor and nonmotor
signs. The current therapeutic regimen for PD is mainly symptomatic as the etio …

The genetics and pathophysiology of Parkinson's disease (PD) strongly implicate
mitochondria in disease aetiology. Elegant studies over the last two decades have …

Mammals' aging is correlated with the accumulation of somatic heteroplasmic mitochondrial
DNA (mtDNA) mutations. Whether and how aging accumulated mtDNA mutations modulate …

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra pars compacta (SNpc). In this study, we generated a transgenic …

Aging is the greatest risk factor for Parkinson's disease (PD), suggesting that mechanisms
driving the aging process promote PD neurodegeneration. Several lines of evidence support …

Mitochondria, the energy stations of the cell, are the only extranuclear organelles, containing
their own (mitochondrial) DNA (mtDNA) and the protein synthesizing machinery. The …

Disease modeling in non-human subjects is an essential part of any clinical research. To
gain proper understanding of the etiology and pathophysiology of any disease, experimental …

Aging in mammals is accompanied by an imbalance of intestinal homeostasis and
accumulation of mitochondrial DNA (mtDNA) mutations. However, little is known about how …

Mitochondria are thought to have become incorporated within the eukaryotic cell
approximately 2 billion years ago and play a role in a variety of cellular processes, such as …

In the cellular context, mitochondria display a number of dynamic behaviors including fusion,
division (or fission), directed transport, and targeted destruction (mitophagy). The relevance …