Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Reactive astrocytes play an important role in neurological diseases, but their molecular and
functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal …

Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

While the central nervous system compromises 2% of our body weight, it harbors up to 25%
of the body's cholesterol. Cholesterol levels in the brain are tightly regulated for …

The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …

Cholesterol homeostasis is vital for brain function. Brain cholesterol is locally synthesized,
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …

Abstract Background Nuclear acetyl-CoA pools govern histone acetylation that controls
synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer's …

Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …

Neurons are particularly susceptible to energy fluctuations in response to stress.
Mitochondrial fission is highly regulated to generate ATP via oxidative phosphorylation; …