Maternal vascular adaptation to pregnancy is critically important in order to expand the
capacity for blood flow through the uteroplacental unit to meet the needs of the developing …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

The mammalian placenta is the organ through which respiratory gases, nutrients, and
wastes are exchanged between the maternal and fetal systems. Thus, transplacental …

Corticosteroid hormones play an important role in the control of vascular smooth muscle
tone by their permissive effects in potentiating vasoactive responses to catecholamines …

Adequate maternal vascular adaptations and blood supply to the uterus and placenta are
crucial for optimal oxygen and nutrient transport to growing fetuses of eutherian mammals …

The last 10 years has seen a dramatic increase in our understanding of the mechanisms
underlying the pregnancy-specific adaptation in cardiovascular function in general and the …

While the etiology of preeclampsia continues to be elucidated, it is clear that preeclampsia is
a complex obstetrical syndrome associated with maternal vascular dysfunction within which …

Normal pregnancy is associated with dramatic increases in uterine blood flow to facilitate the
bidirectional maternal–fetal exchanges of respiratory gases and to provide sole nutrient …

Rapid uterine vasodilatation after estrogen administration is believed to be mediated by
endothelial production of nitric oxide (NO) via endothelial NO synthase (eNOS). However …