Detection of minimal residual disease (MRD) has proven to provide independent prognostic
information for treatment stratification in several types of leukemias such as childhood acute …

The childhood leukemias are a study in contrasts. Acute lymphoblastic leukemia (ALL) is
diagnosed in approximately 2000 children in the United States each year, whereas acute …

In cancer patients, dormant micrometastases are often asymptomatic and clinically
undetectable, for months or years, until relapse. We have studied dormant lung metastases …

We show that homothorax (hth) is required for the Hox genes to pattern the body of the fruit
fly, Drosophila melanogaster. hth is necessary for the nuclear localization of an essential …

Summary Production of interleukin (IL)-10, a major immunoregulatory cytokine, by
phagocytes during clearance of apoptotic cells is critical to ensuring cellular homeostasis …

Abstract Development of mammalian B-lineage cells is characterized by progression
through a series of checkpoints defined primarily by rearrangement and expression of …

The human proto-oncogene PBX1 codes for a homolog of Drosophila extradenticle, a
divergent homeo domain protein that modulates the developmental and DNA-binding …

Summary We report that t (1; 19) ALL cells universally exhibit expression of and
dependence on the cell surface receptor ROR1. We further identify t (1; 19) ALL cell …

Homeobox genes are transcription factors primarily involved in embryonic development.
Several homeobox gene families have so far been identified: Hox, EMX, PAX, MSX as well …

Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy and is
characterized by recurring structural genetic alterations. Previous studies of DNA …