Copper centers in the cryo-EM structure of particulate methane monooxygenase reveal the catalytic machinery of methane oxidation
WH Chang, HH Lin, IK Tsai, SH Huang… - Journal of the …, 2021 - ACS Publications
The particulate methane monooxygenase (pMMO) is the first enzyme in the C1 metabolic
pathway in methanotrophic bacteria. As this enzyme converts methane into methanol …
pathway in methanotrophic bacteria. As this enzyme converts methane into methanol …
Cryo-EM structure of K+-bound hERG channel complexed with the blocker astemizole
T Asai, N Adachi, T Moriya, H Oki, T Maru, M Kawasaki… - Structure, 2021 - cell.com
The hERG channel is a voltage-gated potassium channel involved in cardiac repolarization.
Off-target hERG inhibition by drugs has become a critical issue in the pharmaceutical …
Off-target hERG inhibition by drugs has become a critical issue in the pharmaceutical …
M-Denoiser: Unsupervised image denoising for real-world optical and electron microscopy data
Real-world microscopy data have a large amount of noise due to the limited light/electron
that can be used to capture images. The noise of microscopy data is composed of signal …
that can be used to capture images. The noise of microscopy data is composed of signal …
Deep Spatio-Temporal Network for Low SNR Cryo-EM Movie Frame Enhancement
Cryo-EM in single particle analysis is known to have low SNR and requires to utilize several
frames of the same particle sample to restore one high-quality image for visualizing that …
frames of the same particle sample to restore one high-quality image for visualizing that …
NoiseFlow: Learning optical flow from low SNR Cryo-EM movie
Cryo-EM movie in single particle analysis has extremely low SNR and requires aligning
multiple frames to achieve signal enhancement. Currently, signal processing technique is …
multiple frames to achieve signal enhancement. Currently, signal processing technique is …
Size matters: optimal mask diameter and box size for single-particle cryogenic electron microscopy
T Moriya, N Adachi, M Kawasaki, Y Yamada… - bioRxiv, 2020 - biorxiv.org
Recently it has been demonstrated that single-particle cryogenic electron microscopy (cryo-
EM) at 200 keV is capable of determining protein structures, including those smaller than …
EM) at 200 keV is capable of determining protein structures, including those smaller than …