Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

Over the past two decades, elucidation of the genetic defects that underlie cancer has
resulted in a plethora of novel targeted cancer drugs. Although these agents can initially be …

Non-genetic mechanisms have recently emerged as important drivers of cancer therapy
failure, where some cancer cells can enter a reversible drug-tolerant persister state in …

Drug-tolerant persister cells (persisters) evade apoptosis upon targeted and conventional
cancer therapies and represent a major non-genetic barrier to effective cancer treatment …

Colorectal cancer (CRC) patient-derived organoids predict responses to chemotherapy.
Here we used them to investigate relapse after treatment. Patient-derived organoids expand …

Cancer relapse after chemotherapy remains a main cause of cancer-related death. Although
the relapse is thought to result from the propagation of resident cancer stem cells, a lack of …

Drug-tolerant persister (DTP) cell populations were originally discovered in antibiotic-
resistant bacterial biofilms. Similar populations with comparable features have since been …

Under the selective pressure of therapy, tumours dynamically evolve multiple adaptive
mechanisms that make static interrogation of genomic alterations insufficient to guide …

The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …