MDM2 and MDMX are the primary negative regulators of p53, which under normal
conditions maintain low intracellular levels of p53 by targeting it to the proteasome for rapid …

It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

The INK4a-ARF locus encodes two unrelated proteins that both function in tumor
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …

The cell cycle inhibitor p16 INK4a is inactivated in many human tumors and in families with
hereditary melanoma and pancreatic cancer. Tumor-associated alterations in the INK4a …

Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population
doublings before they cease proliferation and enter a growth-arrest state termed replicative …

The INK4a tumor suppressor locus encodes p16 INK4a, an inhibitor of cyclin D-dependent
kinases, and p19 ARF, an alternative reading frame protein that also blocks cell proliferation …

The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-
dependent kinases CDK4 and CDK6 that blocks them from phosphorylating the …

Since its discovery as a CDKI (cyclin-dependent kinase inhibitor) in 1993, the tumor
suppressor p16 (INK4A/MTS-1/CDKN2A) has gained widespread importance in cancer. The …

The two distinct proteins encoded by the CDKN2A locus are specified by translating the
common second exon in alternative reading frames. The product of the α transcript, p16 …