Glioma is often referred to as one of the most dreadful central nervous system (CNS)-specific
tumors with rapidly-proliferating cancerous glial cells, accounting for nearly half of the brain …

P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …

Gastric cancer (GC) results from deregulated cell growth in the stomach. Despite significant
efforts and recent advancements in the treatment of gastric cancer, it remains a life …

Background Ovarian cancer is a common malignancy in the female reproductive system with
a high mortality rate. The most important reason is multidrug resistance (MDR) of cancer …

Abstract World Health Organisation (WHO) delineated cancer as one of the foremost
reasons for mortality with 10 million deaths in the year 2020. Early diagnosis and effective …

Cancer is currently one of the most intractable diseases causing human death. Although the
prognosis of tumor patients has been improved to a certain extent through various modern …

Colorectal cancer (CRC) is the third most common cancer worldwide. Its poor response to
current treatment options in advanced stages and the need for efficient diagnosis in early …

Nanoparticles as cancer therapeutic carrier fail in clinical translation due to complex
biological environments in vivo consisting of electrolytes and proteins which render …

Cancer immunotherapies have generated some miracles in the clinic by orchestrating our
immune system to combat cancer cells. However, the safety and efficacy concerns of the …

Current chemotherapeutic strategies against various intractable cancers are futile due to
inefficient delivery, poor bioavailability, and inadequate accumulation of anticancer drugs in …