The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …

The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …

Yes-associated protein (YAP) is a key mechanotransduction protein in diverse physiological
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …

Specialized adult somatic cells, such as cardiomyocytes (CMs), are highly differentiated with
poor renewal capacity, an integral reason underlying organ failure in disease and aging …

The nuclear translocation and activity of the cotranscriptional activators YAP and TAZ
(YAP/TAZ) in endothelial cells (ECs) are crucial during developmental angiogenesis. Here …

The transcriptional co-regulators YAP and TAZ pair primarily with the TEAD family of
transcription factors to elicit a gene expression signature that plays a prominent role in …

The Hippo pathway is a crucial signaling mechanism that inhibits the growth of cells and
organs during development and in disease. When the Hippo pathway is activated, YAP/TAZ …

The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration
of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely …

The Hippo signaling pathway is a central growth control mechanism in multicellular
organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo …

The Hippo signalling pathway and its transcriptional co-activator targets Yorkie/YAP/TAZ first
came to attention because of their role in tissue growth control. Over the past 15 years, it has …